| Title |
Tissue-resident NK cells differ in their expression profile of the nutrient transporters Glut1, CD98 and CD71
|
|---|---|
| Published in |
PLOS ONE, July 2018
|
| DOI | 10.1371/journal.pone.0201170 |
| Pubmed ID | |
| Authors |
Wilhelm Salzberger, Gloria Martrus, Kai Bachmann, Hanna Goebels, Leonard Heß, Martina Koch, Annika Langeneckert, Sebastian Lunemann, Karl J. Oldhafer, Caroline Pfeifer, Tobias Poch, Laura Richert, Christoph Schramm, Ramez Wahib, Madeleine J. Bunders, Marcus Altfeld |
| Abstract |
Metabolism is a critical basis for immune cell functionality. It was recently shown that NK cell subsets from peripheral blood modulate their expression of nutrient receptors following cytokine stimulation, demonstrating that NK cells can adjust to changes in metabolic requirements. As nutrient availability in blood and tissues can significantly differ, we examined NK cells isolated from paired blood-liver and blood-spleen samples and compared expression of the nutrient transporters Glut1, CD98 and CD71. CD56bright tissue-resident (CXCR6+) NK cells derived from livers and spleens expressed lower levels of Glut1 but higher levels of the amino acid transporter CD98 following stimulation than CD56bright NK cells from peripheral blood. In line with that, CD56dim NK cells, which constitute the main NK cell population in the peripheral blood, expressed higher levels of Glut1 and lower levels of CD98 and CD71 compared to liver CD56bright NK cells. Our results show that NK cells from peripheral blood differ from liver- and spleen-resident NK cells in the expression profile of nutrient transporters, consistent with a cell-adaptation to the different nutritional environment in these compartments. |
X Demographics
The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Sweden | 3 | 25% |
| United States | 2 | 17% |
| Ireland | 1 | 8% |
| Germany | 1 | 8% |
| United Kingdom | 1 | 8% |
| Unknown | 4 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 67% |
| Scientists | 4 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 77 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 13 | 17% |
| Student > Ph. D. Student | 12 | 16% |
| Researcher | 11 | 14% |
| Student > Doctoral Student | 7 | 9% |
| Student > Bachelor | 6 | 8% |
| Other | 6 | 8% |
| Unknown | 22 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 20 | 26% |
| Biochemistry, Genetics and Molecular Biology | 9 | 12% |
| Medicine and Dentistry | 8 | 10% |
| Agricultural and Biological Sciences | 5 | 6% |
| Arts and Humanities | 2 | 3% |
| Other | 8 | 10% |
| Unknown | 25 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 August 2018.
All research outputs
#4,564,199
of 23,096,849 outputs
Outputs from PLOS ONE
#63,925
of 197,004 outputs
Outputs of similar age
#87,020
of 328,924 outputs
Outputs of similar age from PLOS ONE
#951
of 3,255 outputs
Altmetric has tracked 23,096,849 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 197,004 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.2. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,924 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 3,255 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.